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intermediate and long-term control of Chagas disease vectors in this region requires management of these risk factors.We aimed to investigate the association of CD14 -260C/T (rs256919 polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showe