https://www.selleckchem.com/pr....oducts/tefinostat.ht
After JHTG treatment, there were fewer damaged and apoptotic macrophages, while superoxide dismutase levels were elevated. The JHTG-treated groups also showed reduced ROS levels. The molecular changes following JHTG treatment included decreased expression of NOX4 and p22phox at the protein level and decreased IKK-α, IKK-β, and NF-κB expression at the mRNA level. All of these effects were correlated with the JHTG concentration. These results demonstrated that the molecular mechanism underlying the antioxidant activity of JHTG in macro
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