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7-fold higher than controls (6.1% versus 2.3%, p less then 0.001). In all subjects, blood Pb showed positive correlations with the percentages of Treg cells (r = 0.843, p less then 0.001) and IL-4 (r = 0.473, p = 0.041) while showing an inverse correlation with the percentages of Tc cells (r = -0.563, p = 0.015). These findings indicate that chronic high Pb exposure may cause a shift towards humoral immune response, together with a suppression of cellular immunity, thereby suggesting an elevation in cancer risk in Pb-exposed workers.The