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The pathological components causing POAG pathogenesis are multifactorial and still poorly recognized, however it is generally known that considerably elevated intraocular pressure (IOP) plays a vital role in POAG pathogenesis. Besides, genetic predisposition and aggregation of abrogated proteins in the endoplasmic reticulum (ER) lumen and subsequent activation of this protein kinase RNA-like endoplasmic reticulum kinase (PERK)-dependent unfolded protein response (UPR) signaling pathwa