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9% (P=0.001). Spells' frequency reduction (P=0.001) occurred within 3months with VPA. The independent prdictors for spell' frequency reduction were reduction of anger and crying [OR=4.52(95%CI=2.35-6.04), P =0.01]. VPA therapy reduces CBHS' frequency. Mood improvement is a suggestive effective mechanism. [a]www.clinicaltrials.gov[/a] identifier is NCT04482764. [a]www.clinicaltrials.gov[/a] identifier is NCT04482764.Pseudomonas aeruginosa is a gram-negative bacterium that exists in various ecosystems, causing severe infections in patients with AIDS