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Vitamin D deficiency is evaluated as level of calcidiol less than 20ng/mL, shortage to the level of 21-29 ng/mL, and adequacy level is 30ng/mL.One case of allopurinol-caused rare adverse reactions was reported. One male 51-year-old patient presented blurred vision, streaming eyes, photophobia and blepharospasm sequentially 1 week after oral administration of allopurinol. Complete remission was obtained after Botulinum toxin was locally injected. Allopurinol may cause Meige syndrome-like blepharospasm, the mechanism of which may be related t