https://iq3inhibitor.com/genot....oxic-stress-activate
These multivalent and bi-paratopic VH constructs showed a marked escalation in affinity to Spike (up to 600-fold) and neutralization potency (up to 1400-fold) on pseudotyped SARS-CoV-2 virus when compared to the standalone VH domains. The absolute most powerful binder, a trivalent VH, neutralized authentic SARS-CoV-2 with half-minimal inhibitory focus (IC 50 ) of 4.0 nM (180 ng/mL). A cryo-EM structure associated with trivalent VH bound to Spik
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