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In the one hand, the positive effects of platinum-based chemotherapy on immunomodulation could be utilized to boost the sensitivity of tumor cells to PD-1/PD-L1 inhibitors. On the other hand, platinum-based chemotherapy may upregulate PD-L1 expression in tumor tissue and use a negative immunomodulatory effect, which are often counteracted by PD-1/PD-L1IC50 half maximal inhibitory concentration; IFN interferon; HLA individual leukocyte antigen; NK nor