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The diagnosis of invasive aspergillosis (IA) can be problematic in solid organ transplantation (SOT). The prognosis greatly varies according to the type of transplant, and the impact of prophylaxis is not well-defined. The Diaspersot cohort analyzes the impact of IA in SOT in Spain during the last 10 years. Proven and probable/putative IA were included. We analyzed 126 cases of IA. The incidences of IA were 6.5%, 2.9%, 1.8%, and 0.6% for lung, heart, liver, and kidney transplantation, respectively. EORTC/MSG criteria confirmed only 49.