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220U/L more in the seriously-critically ill group (P0.001). The aspartate aminotransferase (AST) in asymptomatic group and seriously-critically ill group did not decrease significantly (all P 0.05), while the AST in mild-common group decreased significantly (regression coefficient -10.507, P = 0.008). There was no significant difference in AST changes between the three groups (P = 0.250-0.904). Liver injury is common in COVID-19 patients, especially for severe patients; the dynamic change pattern of liver function indicators ma