https://www.selleckchem.com/pr....oducts/Aurora-A-Inhi
To implant in the uterus, the mammalian embryo first specifies two cell lineages the pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms the placenta1. In many organisms, asymmetrically inherited fate determinants drive lineage specification2, but this is not thought to be the case during early mammalian development. Here we show that intermediate filaments assembled by keratins function as asymmetrically inherited fate determinants in the mammalian embryo. Unlike F-actin or microt
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