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Endothelin-1 is a potent vasoconstrictor that plays an integral role when you look at the pathology of pulmonary vascular illness. We used two ovine types of congenital cardiovascular illnesses (1) fetal aortopulmonary graft positioning (shunt), resulting in increased flow and pressure; and (2) fetal ligation for the left pulmonary artery causing increased circulation and typical force off to the right lung, to analyze the theory that ruthless and movement, however circulation alone, upregulates endothe
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