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This analysis identified saquinavir as a potent inhibitor of dimeric SARS-CoV2 Mpro; therefore, the compound may have clinical utility against COVID-19. Graphical abstract. To study and estimate the impact of clinical, somatosensory, and psychosocial variables associated with the concomitant presence of temporomandibular joint (TMJ) pain in patients with TMJ clicking. Ninety-three individuals composed the sample patients with painful TMJ clicking (n = 47) and patients with painless TMJ clicking (n = 46). Four categories of data were ev