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However, the incidence of pancreatic cancer tumors and linked death of pancreatic resections make development of a screening test an arduous, if not impossible, challenge. Intratumoral immunosuppression mediated by myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) presents a possible procedure of protected checkpoint inhibitor (ICI) resistance in solid tumors. By promoting TAM and MDSC infiltration, IL1β may drive adaptive and innate immune weight in renal