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The goal of this paper is to calculate a complex internal respiratory and tumoral movements by measuring respiratory airflows and thorax movements. In this context, we present a new lung tumor tracking approach based on a patient-specific biomechanical model of the respiratory system, which takes into account the physiology of respiratory motion to simulate the real non-reproducible motion. The behavior of the lungs is directly driven by the simulated actions of the breathing muscles, i.e. the diaphragm and the intercostal muscles (the
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