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021 and p = 0.009, respectively). The difference between mild and moderate-to-severe cases for the peripheralcentral guttae ratio was significant (p 0.001). Inter-rater reliability of total guttae count was high (coefficient = 0.82, p 0.001). A peripheralcentral guttae ratio of 0.16 was the ideal cut-off point (area under the curve = 0.79, sensitivity = 0.78, and specificity = 0.8. In this pilot study, the peripheralcentral ratio of guttae correlates with subjective clinical severity of Fuchs dystrophy. It starts at a common ba
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