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The Most Effective ADHD Medication For Adults Stimulants are the first choice of medication for adults with ADHD. They aid in adjusting levels of two chemical messengers within the brain that regulate the attention. Strattera (atomoxetine) is the most effective medication for adhd available for adults. It is available as capsules that can be taken with food or without. It works well for most people. It lasts longer than stimulants with less ti