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How to Choose for Adults Stimulant medications like methylphenidate and amphetamine work by boosting and balancing brain chemicals. Doctors prescribe them as liquids, pills or patches. ADHD can also be treated by healthcare professionals using medications called alpha-2 agonists and norepinephrine-reuptake inhibitors. They are typically used "off-label" for this purpose, since they're FDA-approved for treating other conditions. Stimulants Stimulants are among the most commonly prescribed ADHD medication for ADHD. They increase levels of the brai