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A cross-sectional study ended up being performed among 41 to 60 years older feamales in Dhaka town using a multistage cluster sampling technique and in person meeting. As a whole 326 old females participated in the study, and among them, 30.4% had major depression. No statistically considerable relationship ended up being seen between menopause standing and major despair. Nonetheless, peri-(34.2%) and post-menopausal (33.3%) groups had been much more despondent compared to pre-menopausal (26.8%) groups. Our adjusted analysis indicates,