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Identification of biomarkers to drive treatment using cell-free DNA allows dynamic and safe assessment of tumor biology representing an important advance adding to tissue-based genotyping. Caution must be exercised interpreting commercial matching information as validation is often lacking, and true matching is feasible in a minority of patients.See related article by Vidula et al., p. 3404. To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer. We pursued an unb
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