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How Does ADHD Medication Work? When one neuron sends a signal to another, it uses neurotransmitters, which are chemicals that act as. These chemicals must travel through a small gap that is called a synapse. Certain ADHD medications can make the passing along of these messages more effective. They can assist neurons in the release of more neurotransmitters, or slow down the process of reuptake (called Reuptake inhibitors). Doctors start ADHD patients on a low dosage and monitor t