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Dysregulation of dopamine neurotransmission has been linked to the development of HIV-1 associated neurocognitive disorders (HAND). To investigate the mechanisms underlying this phenomenon, this study utilized an inducible HIV-1 transactivator of transcription (Tat) transgenic (iTat-tg) mouse model, which demonstrates brain-specific Tat expression induced by administration of doxycycline. We found that induction of Tat expression in the iTat-tg mice for either 7 or 14 days resulted in a decrease (~30%) in the Vmax of [3H]DA uptake via bo
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