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Even when the thickness/number of layers was changed variously, no remarkable decrease was observed in the order. Cross-linking between particles by ultraviolet irradiation polymerization was performed for the direct evaluation of the mechanical properties of this structure in the future. Even after topochemical polymerization between the modified chains, the order of the particle stacking structure was maintained.Reports on the comprehensive factors for design considerations of hypoxia-activated prodrugs (HAPs) are rare. We introduced a