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1 2.0 months) and OS (median 12.9 7.8 months) than the irinotecan group in patients with 0 or 1 of these factors, whereas the irinotecan group showed a significantly longer PFS (median 1.0 1.8 months) and a trend of longer OS (median 3.9 6.1 months) in patients with ⩾2 of these factors. Some clinical and molecular factors were associated with outcomes following nivolumab or irinotecan as the third- or later-line treatment in patients with AGC. These factors must be considered while selecting an optimal treatment option. Some clinical