https://www.selleckchem.com/pr....oducts/pf-04929113.h
Resolving the structural variations of individual macromolecular assemblies within inherently heterogeneous populations is paramount for mechanistic understanding of many biological phenomena such as amyloid toxicity and prion strains. The approach presented here will also facilitate the use of AFM for high-resolution structural studies and integrative structural biology analysis of single molecular assemblies.BACKGROUND Physical activity reduces the incidences of noncommunicable diseases, obesity, and mortality, but an inactive lif