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How Does ADHD Medication Work? When a neuron sends an information to another, it uses chemicals called neurotransmitters. These chemicals must pass through a tiny gap known as a synapse. Certain ADHD medications increase the efficiency of these messages. They either aid neurons in releasing more neurotransmitters, or slow down the process of reuptake (called Reuptake inhibitors). Doctors start ADHD patients on a low dosage and then monitor their respo