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Here, we incorporate evolutionary simulations with an analysis of disease sequencing data to explore WGD during cancer tumors advancement. Simulations claim that WGD may be selected to mitigate the permanent, ratchet-like, buildup of deleterious somatic modifications, provided they happen at a sufficiently higher rate. In keeping with this, we observe an enrichment for WGD in cyst kinds with considerable loss of heterozygosity, i