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65; 95% CI 0.64-0.65). A reduction was also observed in the incidence of AS during the PCV13 era compared with the pre-PCV13 era (IRR 0.88; 95% CI 0.88-0.88), mainly driven by declines among those younger than 65 years of age. In contrast, an increase in AS incidence was noted in individuals aged ≥65 years (IRR 1.03; 95% CI 1.02-1.03). A decrease in antibiotic prescription rates for sinusitis was observed for those under 65 years of age. The PCV13 immunization programme is associated with a reduction in the incidence of AOM and AS. More
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