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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with local, systemic inflammation, such as persistent synovial inflammation. Interaction of immune cells and inflammatory mediators results in amplification and perpetuation of inflammatory, remodelling process. This disease is characterized by joints swelling, redness, and arthralgia.We would like to thank our colleagues for their comments on our paper "Is treatment with suspected non-radiographic axial spondyloarthritis effective? Six-month results of a placebo-control