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04; 95% CI 0.02, 0.07). In addition, duloxetine is associated with more treatment-emergent adverse events (TEAEs) (RR 1.25; 95% CI 1.17, 1.33) and discontinuations for adverse events (AEs) (RR 2.31; 95% CI 1.81, 2.94). However, there was no statistically significant difference in serious AEs between duloxetine and placebo. CONCLUSION Duloxetine had modest to moderate effects on pain relief, function improvement, mood regulation and improvement in quality of life with mild AEs in the treatment of OA or CLBP. Future RCTs should focus on com