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8y (SD=15.4y), 62% were male and 49% had diabetes. After HHD treatment failure, adjusted mortality was increased compared to continued HHD at 0-30 days (HR 3.93, 95% CI 2.09-7.40 p0.001), 30-90 days (HR 3.34, 95% CI 1.98-5.62, p0.001) and 90 days (HR 2.29, CI 1.84-2.85, p0.001). Covariates recorded at dialysis initiation. Residual confounding underlying successful initiation of HHD treatment.Observational data lacking detail on cause of HHD treatment failure. HHD treatment failure is associated with a significant increase