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Based on our report, we think that the use of OBZ needs to be carefully discussed in patients with mixed CV. Based on our report, we think that the use of OBZ needs to be carefully discussed in patients with mixed CV. Systemic lupus erythematosus (SLE) patients are considered as a high-risk population for cardiovascular diseases (CVDs). To explore whether their risk is increased already in preclinical episodes of the disease, we have studied the usage of CVD drugs in incident SLE cases five years before diagnosis of SLE compared to the p