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The current study had been aimed to show the big event of extracellular RNAs (exRNAs) in retinal ischemia reperfusion (I/R) injury, and evaluate whether RNase administration can effectivelyreduce I/Rinjury. A retinal I/R injury C57BL/6J wild-type mice model ended up being set up by elevating intraocular pressure for 1 h. All mice got 3 amounts of RNase or even the same dose of regular saline at various time points. After seven days of reperfusion, retinal harm was quantified by counting re