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Adult ADHD and Comorbid Disorders Many people suffering from ADHD suffer from comorbid disorders, like major depression (Kessler and colleagues, 2006). Many patients do not respond to depression medications and may benefit from psychotherapy. Medications that most effectively improve the symptoms of ADHD are those that boost and balance levels of certain neurotransmitters in the brain. Commonly prescribed stimulants include amphetamine, methylphenidate and similar medications. Medicatio