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BACKGROUND The literature surrounding survival of patients with multiple primary melanomas (MPM) yields variable and opposing findings, constrained by statistical challenges. OBJECTIVES To critically examine the available literature regarding survival of patients with MPM compared with single primary melanomas (SPM) and detail statistical methods employed. METHODS Electronic searches of Pubmed, Embase, Web of Science and Scopus, with cross-checking of references, for the period January 1956 - June 2019 were carried out. All studies pub