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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, because they're the most studied and have a fast-acting effect. But they're not right for everyone. These medications increase signaling between nerves and brain regions to lessen ADHD symptoms. They can also have side effects like the loss of appetite or changes in blood pressure or heart rate. Stimulants Stimulants are among the