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1]%, P less then 0.0001), with reductions of T2 observed in the anterior annulus (‑4.4[1.0]%, P=0.00001) and increases in the posterior annulus (2.1[0.8]%, P=0.011). At 6d and 28d post‑bed-rest, IVD T2 was similar compared to baseline for all groups. A similar pattern was seen for IVD height, although a -3.8(4.6)% (P=0.0052) reduction of IVD height was seen 28d after bed-rest in the CNT group. The countermeasures did not impact on the presence or intensity of back pain during or after bed-rest. Participants reporting back pain on day-3 o