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Future TPNP research tends to focus more on complex analysis of mechanisms for diseases treatment, such as toxicology and pharmacology. CONCLUSION This research has firstly demonstrated a comprehensive knowledge map for the existing toxicological and pharmacological researches of natural products, which offered essential instructions on medical application of natural products to future research. INTRODUCTION There is growing evidence that a proportion of patients with Essential Tremor (ET) may develop a memory impairment over time. Howe