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Elevated circulating TNFR1 levels are independently associated with declined intrinsic capacity, suggesting that chronic inflammation may underlie intrinsic capacity decline. Frailty is known to be influenced by genetics, however, little evidence on the association of Apolipoprotein E (ApoE) genotype and frailty exists which we aim to investigate. This study is a cross-sectional analysis from a prospective longitudinal study cohort. Community-dwelling individuals aged 55 years and older from Beijing region in China. A total of 3,569 older