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The binding of chitosan to teichoic acids, essential acids of Gram-positive germs, would trigger a sequence of events and lead to bacterial death.Here, we explain a green method to fabricate genipin crosslinked chitosan-kappa-carrageenan composite hydrogels (C-K hydrogels) aiming at decreasing endotoxin level and germs burden in septic blood synchronously. The chemical compositions and morphologies associated with developed C-K hydrogels had been described as Fourier transform infrared spec