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Median PSAD of patients with non-significant PCa detected by SB was 0.15 ng/mL/cm . Main reasons for missing a csPCa by TB were insufficient prostate segmentation or imprecise lesion registration within MRI/US fusion-guided biopsy. Consequently, verification of MRI quality, exact mCSR assessment, and advanced biopsy experience may improve accuracy. Altogether, an additional SB adds limited clinical benefit in men with PSAD ≤ 0.15 ng/mL/cm . Main reasons for missing a csPCa by TB were insufficient prostate segmentation or imprecise lesio
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