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The ultrasonic atomizer could create a high-frequency vibration to appreciate web removal and nebulization of sample. Then, the produced test droplets could be immediately ionized by the carbon fibre ionization mass spectrometry. UEN/CFI-MS shows great compatibility to solvents and compounds with a wide range of polarity and has now few restrictions for the form of sample. UEN/CFI-MS ended up being successfully requested the quick evaluating of synthetic medications adulterated