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92 [0.41] versus 1.71 [0.31]; P less then 0.001) but not NaF (1.85 [0.28] versus 1.79 [0.60]; P=0.1. NaF uptake was concentrated at carotid bifurcations, while FDG was distributed evenly throughout arteries. Correlations between FDG and NaF TBRmax differed between bifurcations with low macrocalcification (rs=0.38; P less then 0.001) versus high macrocalcification (rs=0.59; P less then 0.001). CONCLUSIONS This is the first study to demonstrate increased uptake of both FDG and NaF in culprit carotid plaques, with discrete distributions