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On the basis of the PPI network of the DEGs, the following 6 candidate genes were identified PIK3R1, RAC1, GNG3, GNAI1, CDC42, and ITGB1. Our data provide a comprehensive bioinformatics analysis of genes, functions, and pathways, which may be related to the pathogenesis of T2DM. Our data provide a comprehensive bioinformatics analysis of genes, functions, and pathways, which may be related to the pathogenesis of T2DM.The National Bureau of Statistics of China shows that the population over 65 years old in China exceeds 166 million account