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ization of the assessment of QoL and the development of a suitable add-on instrument based on the resulting category system of this study. Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokines. Here, we further explored the action of red nucleus IL-33 in the early development of mononeuropathic pain. In this study, male rats with spared nerve injury (SNI) were used as monone