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Recently, designed MSCs target to cell area molecules on immune cells was a unique strategy to improve MSC applications. In this review, we discuss the roles of multiple receptors (ICAM-1, Gal-9, PD-L1, TIGIT, CD200, and CXCR4) along the way of MSCs' immunosuppressive properties. Moreover, we talk about the principles and methods for developing receptor-regulated MSCs and their components of activity while the challenges of using MSCs as immunosuppressive therapies.In this research, the mitogenome