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Medication For ADHD - What Are the Side Effects? Many people with ADHD notice a decrease in symptoms when they use medication. But each person reacts differently to various drugs and the adverse effects can be a problem. Methylphenidate belongs to a class of drugs known as stimulants. works by raising levels of a substance in the brain that assists in controlling the behavior and attention. Stimulant drugs Stimulant medication improves concentration and attention for 70% to 80% children and adults that