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Furthermore, we observed that, for sufficiently high input energies, high frequency harmonics at approximately 45 Hz, were generated in the response of the CC, which, in turn, are associated with high-frequency oscillations of the CC. Such harmonics might potentially lead to strain localization in the CC. This work is a step towards understanding the brain dynamics during traumatic injury. Copyright (c) 2020 by ASME.AIMS Central venous catheter (CVC) related thrombosis is a major cause of CVC dysfunction in patients