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This study's results showed that although both MLP and RBF neural systems are capable to approximate DO, BOD, and COD concentrations, RBF neural system revealed much better performance in comparison to MLP neural network. The outcomes of sensitivity analysis indicated that the parameter CF has got the greatest effect on DO focus estimation. Separate factors CF, iderably lower losings in production system. Graphical abstract.PURPOSE when compared with hospital treatment, bariatric su