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How a VC Can Affect Your Heart Many people experience occasional PVCs and have no issues. If they are frequent, PVCs may weaken your heart and increase the chance of suffering from heart failure. A bundle of fibers in the top right portion of your heart (the sinoatrial node, also known as SA) typically controls your heart's rhythm. Electrical signals travel from this node to the lower chambers of your heart, or ventricles. Causes PVCs are caused when the electrical impulse that normally initiates your heartbe